The effect of drug administration depends not only on the dose and mode of Administration but also on the time of Administration. Ayurveda always gives importance to timely administration of medicines. If medicines are given in inappropriate time then it is not expected to yield optimum result. So Ayurveda explains kshanadi and vyadhiavastha kala while administrative medicine. In each and every minute there will be changes in our body. Many functions of the human body vary throughout day and night. These types of variations caused the biological changes in both healthy and unhealthy state. In other words there will be doshik changes in our body throughout day and night. There will be doshik variations in respect to end, middle, and beginning of the age, day, night, and digestion.
Aushadh Sevan kala plays an important role in deciding the efficacy and intensity of drug dynamics. Single drug and act in many modes depending on time of drug administration. For example avipattikar Churna is given before food for Amalpitta. The same churna acts as malapravarthaka at prabhabhakta. The drug- food interaction and drug- drug interaction also is vital in deciding the extent of drug efficacy. In contemporary science also, importance is given to timely administration of the medicine. The concept of Aushad sevena kala is applicable only for Shamana drugs. Shodhana dravyas are explained separately based on the indication and specific procedure.
Time of drug administration according to different acharyas-
Abhakta means talking Medicine in the morning on empty stomach. According to Chakrapani abhakta means medicine should be taken before food in the morning and food should be given after the complete digestion of medicine. According to Hemadri medicine should be given in kapha udreka atha kala. According to Indu medicine should be given one hour after sunrise. According to ashtang sangraha medicine should be given in the morning after the increased Kapha has moved out of the stomach.
Prabhaktha means administration of medicine just before the intake of food.
Administration of medicine in between meal. Drug is given after consumption of half part of the food and again the other half part of the food is given. According to sushruta madhyabhaktha because of its quality of not spreading cures the disease of koshta as this medicine stays more time in koshta.
Adhobhakta means administration of medicine after intake of food.
Samabhaktha means administration of medicine along with food, mixed with food, either while preparing the food or during administration.
Administration of drugs in between two meal is considered as antharabhaktha. According to Indu, purvahna kala (morning) food should be given initially. Medicine should be given in madhyahna kala after digestion of food. After the digestion of the medicine again food is given in evening.
Administration of medicine just before and after the food. The word samudga means a box like structure.Here ahara should be laghu ( easily digestible food) and alpa (less in quantity)
Here Medicine is given again and again. It doesn’t matter whether the patient has taken the food or not.
In this kala drug should be given along with morsel of food.
Grasanthara means administration of Medicine in between two bolus of food.
Nishi means administration of Medicine at bed time.