Author: Dr Ranjeet Singh
Malaria is a serious life threatening disease caused by parasite called plasmodium. It is one of the global killer disease specially in poor, forested, hilly, remote regions with some little facilities. Every year about 2 million malaria cases are recorded as per the National Malaria Research Institute. Sometimes it spreads like epidemic and becomes fatal. It is known as Visham Jvara in Ayurvedic literature.
Among all tropical diseases, Malaria is one of the most prevalent, destructive, widely spread disease condition and well known to Ayurvedic Physicians since ancient times. Description considering aetiopathogenesis, clinical features and line of management are detailed under Vishamajvara in ancient classical literature of Ayurveda. Considering its wide prevalance and developing drug resistance to malarial parasite, CCRAS has developed a polyherbal non-toxic, anti-malarial drug-AYUSH-64 through extensive pharmacological, toxicological and clinical studies.
Each tablet of AYUSH-64 contains-
- Saptaparna stem Bark (Alstonia sholaris) =100mg
- Katuki (Picrorhiza kurroa) =100mg
- Chiyayata whole plant (Swertia chirata) =100mg
- Kuberaksha (Caesalpinia crista) =200mg
General clinical trials
Clinical trials of AYUSH-64 were conducted on 1442 positive cases of malaria at various Research Institutes and Centres of the Council located in different parts of the country. The response of treatment was 89% and the findings were comparable with known Anti-malarial drugs- Chlroquine and primaquine.
Double blind studies
OPD and IPD level double blind clinical studies were conducted on 178 patients which revealed that the drug is effective in 95.4% of patients. The drug showed effect both against fever and the Parasite.
During Epidemic Malarial control programmes at Rajasthan and Assam approximately 3600 and 1000 P. vivex cases were treated respectively. P. falciparum was observed in some cases and parasite clearance and clinical improvement was found in few number of cases.
No side effects or toxic effects in prescribed doses.
Adult: 4 tablet ( 500mg per tab.), thrice a day for 5-7 days
Children (5-12 years): 2 tablets, thrice a day for 5-7 days
Infants (below 5 years): Powder of 1 tablet with honey, thrice a day
(Source: CCRAS, ministry of AYUSH)